C3 Glomerulopathy — Advanced

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Difficulty: Advanced

Postgraduate self-assessment focused on C3 Glomerulopathy. Complete all 10 questions to view detailed clinical explanations on the results page.

Advanced postgraduate nephrology self-assessment on C3 Glomerulopathy. Difficulty: Advanced. Explanations are shown after quiz completion.

1 / 10

C3 glomerulopathy is primarily caused by dysregulation of:

The alternative complement pathway

The coagulation cascade only

The classical pathway exclusively

Renin secretion

2 / 10

The characteristic immunofluorescence finding is dominant deposition of:

Linear IgG only

C3 with absent or limited immunoglobulin

IgA alone in every case

C1q only

3 / 10

Which serum complement result is common in active C3 glomerulopathy?

Always low C4 with normal C3

High C3 in every patient

Low C3

Absent serum albumin by definition

4 / 10

A useful evaluation in C3 glomerulopathy includes:

Only serum sodium

Only anti-PLA2R antibody

No evaluation for monoclonal gammopathy

Complement studies, nephritic-factor testing, and assessment for genetic or secondary drivers

5 / 10

Dense deposit disease is distinguished ultrastructurally by:

Highly electron-dense intramembranous deposits within the GBM

Subepithelial humps only

Linear IgG deposits only

Amyloid fibrils

6 / 10

C3 glomerulopathy may clinically present with:

Only isolated edema with no urinary abnormalities

Hematuria, proteinuria, hypertension, and progressive kidney dysfunction

Only hypernatremia

Exclusive pulmonary hemorrhage

7 / 10

A monoclonal gammopathy in an adult with C3 glomerulopathy is important because it may:

Exclude kidney disease

Guarantee spontaneous remission

Drive complement dysregulation and require clone-directed evaluation

Only cause respiratory alkalosis

8 / 10

Kidney biopsy is important in suspected C3 glomerulopathy because it:

Replaces all complement testing

Is unnecessary when C3 is low

Diagnoses every genetic mutation

Establishes the pattern of complement-dominant glomerular injury and chronicity

9 / 10

Treatment of C3 glomerulopathy should first address:

Supportive kidney care and any identifiable secondary driver

Routine high-dose immunosuppression for every patient

Avoidance of blood-pressure control

No assessment of proteinuria

10 / 10

A major prognostic marker in C3 glomerulopathy is:

A single normal C3 measurement

Persistent proteinuria and declining eGFR

Hair loss

Serum chloride alone

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C3 Glomerulopathy — Advanced

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